Biological functions of mesenchymal stem cells and clinical implications

Biological functions of mesenchymal stem cells and clinical implications Mesenchymal stem cells (MSCs) are isolated from various biological tissues, including adult bone marrow, adipose tissues, and neonatal tissues like the umbilical cord and placenta. MSCs exhibit biological properties such as extensive proliferation ability and multipotency in vitro. Furthermore, MSCs have been shown to have trophic, …

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A revealing review of mesenchymal stem cells therapy, clinical perspectives, and Modification strategies

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A revealing review of mesenchymal stem cells therapy, clinical perspectives, and Modification strategies Mesenchymal stem cells (MSCs) are hierarchical postnatal stem cells capable of self-renewal and maintaining a diverse power of differentiation across multiple lineages. MSCs are emerging as a prominent topic in recent research due to their biological and clinical importance. Applications. MSCs possess …

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Hematopoietic stem cell transplantation for autoimmune diseases.

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Hematopoietic stem cell transplantation for autoimmune diseases. Autologous hematopoietic stem cell transplantation (HSCT) is the only treatment that can induce long-term, drug-free, symptom-free remission in multiple refractory autoimmune rheumatic diseases. More than 3,000 HSCT interventions have been performed worldwide for severe rheumatic and non-rheumatic autoimmune disorders. Currently, specific conditioning schemes are used to eradicate autoreactive …

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What are some of the potentials of MSCs in many in vitro and in vivo models?

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What are some of the potentials of MSCs in many in vitro and in vivo models? MSC potentials in vitro It sounds like you are interested in the potential uses of mesenchymal stem cells (MSCs) in in vitro (meaning “in glass” or “in a laboratory dish”) settings. MSCs are a type of stem cell that …

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Advances in mesenchymal stem cell exosomes

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Advances in mesenchymal stem cell exosomes In 1983, exosomes were discovered in sheep reticulocytes but were initially considered cellular debris. In 2007, scientists found that these nanometer-sized vesicles (exosomes) contain proteins, lipids, and RNA, including mRNA and miRNA. Exosomes can be passed on to other cells as signaling molecules that perform biological functions and, due …

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Stem cells: past, present, and future Stem Cells

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Stem cells: past, present, and future Stem Cells INTRODUCTION: Stem cells are primitive cells found in all multicellular organisms that can renew themselves through cell division and differentiate into specialized cell types. Stem cell research in organ transplantation and tissue replacement has given modern therapeutics much hope. Due to their self-renewal and potency, stem cells …

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The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome

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The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome The mesenchymal stem cell In 1970, Till and McCullagh in Canada observed the hematopoietic stem molecular (HSC). This was the first adult stem molecular to be followed. This discovery became quickly exploited clinically with the creation within the overdue Nineteen Sixties …

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Mesenchymal stem cell therapies for autoimmune diseases

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Mesenchymal stem cell therapies for autoimmune diseases Mesenchymal stem cells (MSCs): Mesenchymal stem cells (MSCs) are a type of adult stem cell that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells). They are found in many tissues in the body, including bone marrow, fat …

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Mesenchymal Stem Cell Therapy for Heart Disease

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Cardiovascular disease is the leading cause of mortality and morbidity in the US and worldwide. Cardiovascular disease, mainly due to myocardial infarction (MI) and its fatal consequences, heart failure and sudden cardiac death, places an enormous psychological and financial burden on patients, their families, and society. Over the past half-century, conventional medicine and surgery have …

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Mesenchymal stem cells (MSCs) where do they come from and is it important

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Mesenchymal stem cells (MSCs) where do they come from and is it important Mesenchymal stem cells (MSCs): Mesenchymal stem cells (MSCs) are a type of adult stem cell that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells). They are found in many tissues in …

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